An indirect method for absorption rate estimation: Flurothyl-induced seizures
An indirect method for absorption rate estimation: Flurothyl-induced seizures
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DOI：
10.1007/bf02459466
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发表时间：
1997-05-01
影响因子：
3.5
通讯作者：
Velisek, L
中科院分区：
文献类型：
--
作者：
Lansky, P;Veliskova, J;Velisek, L
本文开发了一种方法来估计诱导癫痫发作所需的最小量的氟乙酸（癫痫发作阈值）。提出了一个简单的数学模型，它允许一个确定的药物吸收率的量已被管理，并从测得的潜伏期发作。实验动物（大鼠）在两种不同的情况下连续摄入氟乙脂：单独在密闭室中或成对共享。在后一种情况下，我们假设两只大鼠均匀地共享输注的药物。我们的计算估计，诱导抽搐需要大约20 μ l的氟乙酰，而诱导阵挛性癫痫发作需要25 μ l的氟乙酰。该模型可用于估计阈值量的任何药物产生明显的行为变化，无论给药途径。(C)1997年，数学生物学学会。
This paper develops a method to estimate a minimal amount of flurothyl necessary to induce the seizures (the seizure threshold). A simple mathematical model is proposed which permits one to determine the drug absorption rate from the amount which has been administered and from the measured latency to onset of seizure. Experimental animal (rats) were exposed to a continuous intake of flurothyl in two different situations: either being alone in the airtight chamber or sharing it in a pair. In the latter case, we assume that the two rats uniformly share the infused drug. Our calculations estimate that approximately 20 mu l of flurothyl is necessary to induce twitches, whereas 25 mu l of flurothyl is the dose required for the induction of clonic seizures. The model can be used to estimate the threshold amounts of any drug producing obvious behavioral changes irrespective of the route of administration. (C) 1997 Society for Mathematical Biology.