HERITABLE FORMATION OF PANCREATIC BETA-CELL TUMORS IN TRANSGENIC MICE EXPRESSING RECOMBINANT INSULIN SIMIAN VIRUS-40 ONCOGENES
HERITABLE FORMATION OF PANCREATIC BETA-CELL TUMORS IN TRANSGENIC MICE EXPRESSING RECOMBINANT INSULIN SIMIAN VIRUS-40 ONCOGENES
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DOI：
10.1038/315115a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
HANAHAN, D
中科院分区：
文献类型：
--
作者：
HANAHAN, D
将大鼠胰岛素II基因上游与SV - 40大t抗原编码序列相关的重组基因转入受精卵后，大t抗原仅在. β中检测到。-转基因小鼠内分泌胰腺细胞。.alpha。而通常在朗格汉斯岛发现的δ细胞则是罕见且紊乱的。Well-vascularized度量。携带和继承这些混合癌基因的小鼠会产生-细胞肿瘤。
Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of SV 40, large-T antigen was detected exclusively in the .beta.-cells of the endocrine pancrease of transgenic mice. The .alpha. and .delta.-cells normally found in the islets of Langerhans were rare and disordered. Well-vascularized .beta.-cell tumors arise in mice harboring and inheriting these hybrid oncogenes.