Determination and stability of gonadal sex.
Determination and stability of gonadal sex.
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DOI：
10.2164/jandrol.109.008201
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发表时间：
2010-01
影响因子：
--
通讯作者：
Pelosi E
中科院分区：
文献类型：
--
作者：
Schlessinger D;Garcia-Ortiz JE;Forabosco A;Uda M;Crisponi L;Pelosi E
SRY基因在人类和其他哺乳动物中诱导雄性性别的发现引发了对雌性性别可能等价物的猜测。但事实证明，女性更复杂。几个主基因似乎是自主参与，女性性别决定似乎仍然相对不稳定。转录因子FOXL 2功能的部分丧失导致女性卵巢早衰;在动物模型中，Foxl 2是卵泡发生以及维持和可能诱导女性性别决定所必需的。在生殖细胞系中，卵母细胞形成明显正常，即使在Foxl 2的情况下，依赖于包括女性特异性因子如Fig-alpha，Nobox等的基因。在索马中，Foxl 2或独立表达的基因Wnt 4（可能在Rspo 1的下游）的消融可以在XX小鼠中产生部分睾丸分化，并且双敲除导致小管和精原细胞的形成。这表明，至少需要两个自主的卵巢途径来拮抗雌性睾丸分化，这一发现越来越多地被山羊和非哺乳类脊椎动物的研究所证实。在最近的小鼠卵巢表达谱缺乏Foxl 2单独或与Wnt 4或Kit/c-Kit组合，我们发现，Foxl 2损失后，早期睾丸基因（包括Sry，Sox 9的下游效应）和几个新的卵巢基因在胚胎-胎儿发育过程中一致失调。结果支持剂量依赖性Foxl 2功能和抗睾丸作用的建议。提出了体细胞发育和性别决定的部分工作模型，其中Sox 9是支持细胞谱系中Foxl 2的直接拮抗剂。
The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. But females are proving to be more complicated. Several master genes appear to be autonomously involved, and female sex determination seems to remain relatively labile. Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women; and in animal models, Foxl2 is required for folliculogenesis as well as for maintenance, and possibly induction, of female sex determination. In the germ line, oocytes form apparently normally even in the absence of Foxl2, dependent on genes that include female-specific factors such as Fig-alpha, Nobox, etc. In the soma, ablation of Foxl2 or the independently expressed gene Wnt4 (likely downstream of Rspo1) can produce partial testis differentiation in XX mice, and the double knockout results in the formation of tubules and spermatogonia. This indicates that at least two autonomous ovarian pathways are required to antagonize testis differentiation in females, a finding that is being increasingly corroborated by studies in goats and non-mammalian vertebrates. In recent expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit, we found that following Foxl2 loss, early testis genes (including the downstream effector of Sry, Sox9) and several novel ovarian genes were consistently dysregulated during embryo-fetal development. The results support the proposal of dose-dependent Foxl2 function and anti-testis action. A partial working model for somatic development and sex determination is presented in which Sox9 is direct antagonist of Foxl2 in the supporting cell lineage.
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影响因子：
--
作者：
Garcia-Ortiz JE;Pelosi E;Omari S;Nedorezov T;Piao Y;Karmazin J;Uda M;Cao A;Cole SW;Forabosco A;Schlessinger D;Ottolenghi C
通讯作者：
Ottolenghi C
DOI：
10.1056/nejmoa0806228
发表时间：
2009-03-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lourenço D;Brauner R;Lin L;De Perdigo A;Weryha G;Muresan M;Boudjenah R;Guerra-Junior G;Maciel-Guerra AT;Achermann JC;McElreavey K;Bashamboo A
通讯作者：
Bashamboo A
影响因子：
3.5
作者：
Chassot, Anne-Amandine;Ranc, Fariba;Chaboissier, Marie-Christine
通讯作者：
Chaboissier, Marie-Christine
DOI：
10.1073/pnas.0600994103
发表时间：
2006-08-08
影响因子：
11.1
作者：
Gao, Fei;Maiti, Sourindra;Huff, Vicki
通讯作者：
Huff, Vicki
影响因子：
4.4
作者：
Crisponi, L;Uda, M;Pilia, G
通讯作者：
Pilia, G