Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures.
Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures.
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DOI：
10.1117/1.jbo.20.8.086005
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发表时间：
2015-08
影响因子：
3.5
通讯作者：
Desjardins AE
中科院分区：
文献类型：
--
作者：
Xia W;Nikitichev DI;Mari JM;West SJ;Pratt R;David AL;Ourselin S;Beard PC;Desjardins AE
精确的设备引导对于许多不同临床领域的介入手术非常重要，包括胎儿医学、区域麻醉、介入疼痛管理和介入肿瘤学。虽然超声波在临床实践中广泛用于实时引导，但其提供的图像对比度可能不足以可视化血管、神经和肿瘤等组织结构。这项研究的重点是开发用于介入手术的光声成像系统，该系统通过位于针插管中的光纤提供 750 至 900 nm 和 1150 至 1300 nm 范围内的激发光。获得配准的 B 型超声图像。该系统基于商用超声成像扫描仪，轴向分辨率约为 100 μm，横向分辨率为亚毫米、与深度相关。使用组织模型和 800 nm 激发光，可以在距针尖最大距离 15 mm 处可视化模拟血管。用离体组织样本观察血红蛋白和脂质的光谱对比度，光声信号最大值与各自的光学吸收光谱一致。讨论了系统进一步优化的潜力。
Precise device guidance is important for interventional procedures in many different clinical fields including fetal medicine, regional anesthesia, interventional pain management, and interventional oncology. While ultrasound is widely used in clinical practice for real-time guidance, the image contrast that it provides can be insufficient for visualizing tissue structures such as blood vessels, nerves, and tumors. This study was centered on the development of a photoacoustic imaging system for interventional procedures that delivered excitation light in the ranges of 750 to 900 nm and 1150 to 1300 nm, with an optical fiber positioned in a needle cannula. Coregistered B-mode ultrasound images were obtained. The system, which was based on a commercial ultrasound imaging scanner, has an axial resolution in the vicinity of 100 μm and a submillimeter, depth-dependent lateral resolution. Using a tissue phantom and 800 nm excitation light, a simulated blood vessel could be visualized at a maximum distance of 15 mm from the needle tip. Spectroscopic contrast for hemoglobin and lipids was observed with ex vivo tissue samples, with photoacoustic signal maxima consistent with the respective optical absorption spectra. The potential for further optimization of the system is discussed.