Current views on the mechanisms of immune responses to trauma and infection.
Current views on the mechanisms of immune responses to trauma and infection.
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目前对创伤和感染免疫反应机制的看法。
DOI：
10.5114/ceji.2015.52835
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Słotwiński R
中科院分区：
文献类型：
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作者：
Binkowska AM;Michalak G;Słotwiński R
根据世界卫生组织的数据，创伤后死亡率仍然很高，并呈上升趋势。先天免疫反应障碍可能会增加严重并发症的风险，在免疫系统对创伤和感染的反应中发挥着关键作用。这些疾病的机制是多因素的，目前仍知之甚少。全身性炎症反应综合征(SIRS)和代偿性抗炎反应综合征(CARS)早期炎症反应的概念变化，在这项工作中提出，已扩展到遗传学研究。基因过度表达和免疫反应介质的产生增加是多器官功能障碍综合征(MODS)的主要原因之一。损伤后早期检测到的基因表达变化先于后续并发症的发生，具有典型的临床特征。能源的迅速枯竭导致免疫抑制和持续性炎症和免疫抑制分解代谢综合征(PICS)。早期诊断免疫紊乱和适当的营养治疗可以显著降低并发症的发生率、住院时间和死亡率。这项研究介绍了对创伤和感染的免疫反应机制的知识和当前观点的发展。
According to the World Health Organization, post-traumatic mortality rates are still very high and show an increasing tendency. Disorders of innate immune response that may increase the risk of serious complications play a key role in the immunological system response to trauma and infection. The mechanism of these disorders is multifactorial and is still poorly understood. The changing concepts of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) early inflammatory response, presented in this work, have been extended to genetic studies. Overexpression of genes and increased production of immune response mediators are among the main causes of multiple organ dysfunction syndrome (MODS). Changes in gene expression detected early after injury precede the occurrence of subsequent complications with a typical clinical picture. Rapid depletion of energy resources leads to immunosuppression and persistent inflammation and immune suppression catabolism syndrome (PICS). Early diagnosis of immune disorders and appropriate nutritional therapy can significantly reduce the incidence of complications, length of hospital stay, and mortality. The study presents the development of knowledge and current views explaining the mechanisms of the immune response to trauma and infection.