Human papillomavirus type 52: a new virus associated with cervical neoplasia.
Human papillomavirus type 52: a new virus associated with cervical neoplasia.
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人乳头瘤病毒 52 型：一种与宫颈肿瘤相关的新病毒。
DOI：
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发表时间：
1988
影响因子：
3.8
通讯作者：
Wayne D. Lancaster
中科院分区：
文献类型：
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作者：
Kouji Shimoda;Attila T. Lorincz;G F Temple;Wayne D. Lancaster
宫颈上皮内瘤样病变（CIN）活检的分析显示，高比例的人乳头瘤病毒（HPV）序列，将杂交的HPV探针的混合物，只有在宽松的严格条件下。这些病毒之一的DNA序列被分子克隆，并显示为一种新的HPV，52型（HPV-52）。该病毒与HPV-33关系最密切。与HPV-52限制性片段的杂交分析显示与HPV-33基因组共线性。DNA测序显示两种病毒在L1开放阅读框架内高度保守，但在病毒基因组的非编码区存在显著差异。流行率研究表明，在美国研究的137例CIN中有3例（2%）和48例宫颈鳞状细胞癌中有1例（2%）存在HPV-52序列。
Analysis of biopsies of cervical intraepithelial neoplasia (CIN) revealed a high percentage of human papillomavirus (HPV) sequences that would hybridize to a mixture of HPV probes only under conditions of relaxed stringency. The DNA sequences of one of these viruses was molecularly cloned and shown to be a new HPV, type 52 (HPV-52). This virus is most closely related to HPV-33. Hybridization analysis with restriction fragments of HPV-52 showed collinearity with the HPV-33 genome. DNA sequencing revealed a high level of conservation between the two viruses within the L1 open reading frame but significant divergence in the non-coding region of the viral genomes. Prevalence studies indicated that HPV-52 sequences were present in three of 137 (2%) CIN and in one of 48 (2%) cervical squamous cell cancers studied in the U.S.A.
特定人乳头瘤病毒类型与宫颈肿瘤的致癌关联。
DOI：
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发表时间：
1987
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Lorincz,AT;Temple,GF;Kurman,RJ;Jenson,AB;Lancaster,WD
通讯作者：
Lancaster,WD