Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort.
Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort.
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DOI：
10.2337/diabetes.51.5.1644
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发表时间：
2002-05
期刊：
影响因子：
7.7
通讯作者：
T. Fingerlin;M. Erdos;R. Watanabe;K. Wiles;H. Stringham;K. Mohlke;K. Silander;T. Valle;T. Buchanan;J. Tuomilehto;R. Bergman;M. Boehnke;F. Collins
中科院分区：
文献类型：
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作者：
T. Fingerlin;M. Erdos;R. Watanabe;K. Wiles;H. Stringham;K. Mohlke;K. Silander;T. Valle;T. Buchanan;J. Tuomilehto;R. Bergman;M. Boehnke;F. Collins
钙蛋白酶-10基因的变异最近被报道与墨西哥裔美国人中的2型糖尿病有关。我们对钙蛋白酶-10基因的三个单核苷酸多态性（SNPs）进行了分型，（SNPs 43，56和63），以测试这些基因座的变异与1,603名芬兰受试者的2型糖尿病和糖尿病相关性状之间的关联：526个样本中的两个样本（芬兰-美国NIDDM遗传学研究[FUSION] 1）和255（FUSION 2）2型糖尿病的索引病例受试者，185和414例FUSION 1索引病例受试者或其受累同胞的未受影响的配偶和后代，以及223例正常葡萄糖耐受的老年对照受试者。我们发现，糖尿病患者与老年人和配偶对照人群之间的等位基因、基因型、单倍型或单倍基因型频率无显著差异（均P > 0.087）。虽然这三个SNPs的变异与每个病例组和对照组中的一些2型糖尿病相关性状的变异相关，但没有发现所涉及的变异或变异组合的一致模式。我们的结论是，在这三个单核苷酸多态性的钙蛋白酶-10基因的变化是不太可能赋予2型糖尿病的易感性，在这个芬兰队列。
Variations in the calpain-10 gene have recently been reported to be associated with type 2 diabetes in a Mexican-American population. We typed three single nucleotide polymorphisms (SNPs) in the calpain-10 gene (SNPs 43, 56, and 63) to test for association between variation at these loci and type 2 diabetes and diabetes-related traits in 1,603 Finnish subjects: two samples of 526 (Finland-U.S. Investigation of NIDDM Genetics [FUSION] 1) and 255 (FUSION 2) index case subjects with type 2 diabetes, 185 and 414 unaffected spouses and offspring of FUSION 1 index case subjects or their affected siblings, and 223 elderly normal glucose-tolerant control subjects. We found no significant differences in allele, genotype, haplotype, or haplogenotype frequencies between index case subjects with diabetes and the elderly and spouse control populations (all P > 0.087). Although variation in these three SNPs was associated with variation in some type 2 diabetes-related traits within each of the case and control groups, no consistent pattern of the implicated variant or combination of variants was discerned. We conclude that variation in these three SNPs in the calpain-10 gene is unlikely to confer susceptibility to type 2 diabetes in this Finnish cohort.