Reduced top-down influences in contour detection in schizophrenia.
Reduced top-down influences in contour detection in schizophrenia.
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DOI：
10.1080/13546800444000209
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发表时间：
2006-03-01
影响因子：
1.7
通讯作者：
Savitz, Adam
中科院分区：
文献类型：
--
作者：
Silverstein, Steven M;Hatashita-Wong, Michi;Savitz, Adam
引言：慢性精神分裂症患者先前表现出轮廓整合任务的性能缺陷。本研究的目的是调查精神分裂症患者，跨越一系列的疾病严重程度，是否会表现出反应的操作，招聘自上而下的处理策略，涉及学习和排序的影响，在轮廓integrationtask.METHODS：我们管理的轮廓整合测试连续四天，每天在两个不同的介绍条件。在一种情况下，刺激是按照难度增加的顺序进行的，而在另一种情况下，刺激是按照随机顺序进行的。这两个条件的呈现顺序在不同的日期和参与者中得到了平衡。此外，一个非精神分裂症的精神障碍对照组，以确定是否可以复制在一个类似的对照group.RESULTS存在的轮廓整合缺陷的精神分裂症的过去的调查结果：所有组表现出类似的学习曲线在四天内，一般相似的整体水平的性能，除了最慢性精神分裂症患者的组。此外，刺激的顺序被提交给受试者影响他们的表现，与较高的分数实现了所有组的条件下，刺激的难度增加的顺序。互动效应显示，顺序介绍的效果是更大的非病人比精神病patients.CONCLUSIONS：这些数据进一步证明，知觉组织障碍在精神分裂症的疾病严重程度相关，精神分裂症患者作为一个整体是不太敏感的自上而下的操作，在这种类型的任务。
INTRODUCTION: Chronic schizophrenia patients have previously demonstrated performance deficits in contour integration tasks. The purpose of this study was to investigate whether schizophrenia patients, spanning a range of illness severity, would demonstrate responsiveness to manipulations that recruit top-down processing strategies involving learning and sequencing effects in a contour integration task.METHODS: We administered a contour integration test over four consecutive days and in two different presentation conditions each day. In one condition, the stimuli were administered in order of increasing difficulty, and in the other they were presented in random order. The order in which these two conditions were presented was counterbalanced across days and participants. In addition, a nonschizophrenia psychotic disorders control group was included to determine if past findings of a contour integration deficit in schizophrenia could be replicated in the presence of a symptomatically similar control group.RESULTS: All groups demonstrated similar learning curves across the four days and generally similar overall levels of performance, with the exception of the group of the most chronic schizophrenia patients. In addition, the order in which the stimuli were presented to subjects affected their performance, with higher scores achieved for all groups in the condition where the stimuli were presented in increasing order of difficulty. Interaction effects revealed that the effects of order presentation were greater for nonpatient than for psychotic patients.CONCLUSIONS: These data are further evidence that perceptual organization impairments in schizophrenia are illness severity-related, and that schizophrenia patients as a whole are less sensitive to top-down manipulations in this type of task.