Down syndrome and the autonomic nervous system, an educational review for the anesthesiologist.
Down syndrome and the autonomic nervous system, an educational review for the anesthesiologist.
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DOI：
10.1111/pan.14416
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发表时间：
2022-05
影响因子：
1.7
通讯作者：
Wiley, Susan
中科院分区：
文献类型：
--
作者：
Sinton, Jamie W.;Cooper, David S.;Wiley, Susan
在美国，大约每700个婴儿中就有一个出生时患有唐氏综合症，即0.14%。患有唐氏综合症的儿童有认知障碍和先天性畸形，需要经常进行全身麻醉和手术。对于儿科麻醉师来说，唐氏综合症儿童的周到围手术期护理是相关且极其复杂的。除了外科病理学之外，行为、镇静、张力减退、上呼吸道阻塞、静脉通路和心动过缓也是普遍存在的问题。唐氏综合征也与自主神经系统功能障碍有关，这是一种在围手术期护理讨论中被忽视的合并症，迄今为止在成人中有描述。自主神经系统功能或功能障碍可以解释上述围手术期挑战的表型特征。因此，了解自主神经系统功能的发展和测量对儿科麻醉医生来说是很重要的。交感神经和副交感神经功能的定义和量化将进行审查。
Approximately one in every 700 babies in the United States is born with Down syndrome, or 0.14%. Children with Down syndrome have cognitive impairment and congenital malformations necessitating frequent occurrences of general anesthesia and surgery. The thoughtful perioperative care of children with Down syndrome is relevant and acutely complex for the pediatric anesthesiologist. Behavior, sedation, hypotonia, upper airway obstruction, venous access, and bradycardia are omnipresent concerns apart from the surgical pathology. Down syndrome is also associated with autonomic nervous system dysfunction, a comorbidity that is overlooked in discussions of perioperative care and is described thus far in adults. Autonomic nervous system function or dysfunction may explain the phenotypical features of the perioperative challenges listed above. For this reason, understanding the development and measurement of autonomic nervous system function is important for the pediatric anesthesiologist. Definition and quantification of sympathetic and parasympathetic function will be reviewed.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
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