The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease.

The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease.
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DOI:
10.1016/j.micinf.2009.08.003
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发表时间:
2009-12
影响因子:
5.8
通讯作者:
Darwin KH
Darwin KH
中科院分区:
医学3区
文献类型:
--
作者:
Cerda-Maira F;Darwin KH

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In eukaryotes the proteasome is responsible for the degradation of many proteins that are targeted for turnover by post-translational modification with ubiquitin. A similar system was identified in Mycobacterium tuberculosis and has shown to be essential for the pathogenesis of this bacterium. Here, we overview the current information of the Mtb proteasome and discuss the role of this protease in pathogenesis.
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