Prostate mechanical imaging: A new method for prostate assessment
Prostate mechanical imaging: A new method for prostate assessment
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DOI：
10.1016/j.urology.2007.11.021
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发表时间：
2008-03-01
期刊：
影响因子：
2.1
通讯作者：
Sarvazyan, Armen
中科院分区：
文献类型：
--
作者：
Weiss, Robert E.;Egorov, Vladimir;Sarvazyan, Armen
目的评价前列腺机械成像(PMI)技术提供客观、可重复性的图像和评估前列腺结节的能力。对168名年龄在44岁至94岁之间的患者进行了PMI检查，并与直肠指诊(DRE)结果进行了比较。对21例前列腺特异性抗原水平升高的患者的PMI和DRE结果进一步与经直肠前列腺超声(TRUS)引导的活检结果进行相关性检验。结果在84%的病例中，PMI设备能够重建前列腺的三维(3D)和2D横断面图像。在13例经活检证实为恶性包涵体的患者中，PMI系统和DRE预测试验分别能够确定10例和6例恶性结节。PMI系统结果与所有8例活检阴性病例一致，而DRE有1例异常读数。PMI和DRE检测可触及结节的符合率为81%，如接收器工作特征曲线下面积所示。PMI和DRE对前列腺大小的估计在统计学上显著相关。结论PMI有可能使医生能够根据腺体及其内部结构的机械和几何特征获得、检查和存储前列腺的3D图像。
OBJECTIVES To evaluate the ability of prostate mechanical imaging (PMI) technology to provide an objective and reproducible image and to assess the prostate nodularity.METHODS We evaluated the PMI device developed by Artann Laboratories in a pilot clinical study. For the 168 patients (ages 44 to 94) who presented to an urologist for prostate evaluation, PMI-produced images and assessment of prostate size, shape, consistency/hardness, mobility, and nodularity were compared with digital rectal examination (DRE) findings. The PMI and DRE results were further tested for correlation against a transrectal ultrasound of the prostate (TRUS) guided biopsy for a subgroup of 21 patients with an elevated prostate-specific antigen level.RESULTS In 84% of the cases, the PMI device was able to reconstruct three-dimensional (3D) and 2D cross-sectional images of the prostate. The PMI System and DRE pretests were able to determine malignant nodules in 10 and 6 patients, respectively, of the 13 patients with biopsy-confirmed malignant inclusions. The PMI System findings were consistent with all 8 biopsy negative cases, whereas the DRE had 1 abnormal reading for this group. The correlation between PMI and DRE detection of palpable nodularity was 81%, as indicated by the area under the receiver operating characteristic curve. Estimates of the prostate size provided by PMI and DRE were statistically significantly correlated.CONCLUSIONS The PMI has the potential to enable a physician to obtain, examine, and store a 3D image of the prostate based on mechanical and geometrical characteristics of the gland and its internal structures.