Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
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DOI：
10.1007/978-1-61779-458-2_23
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发表时间：
2012-01-01
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影响因子：
--
通讯作者：
Hoebel, Bartley G.
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文献类型：
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作者：
Avena, Nicole M.;Bocarsly, Miriam E.;Hoebel, Bartley G.
暴饮暴食是一种发生在某些饮食失调、肥胖和非临床人群中的行为。糖和脂肪都很容易被人类消耗，是狂欢的常见成分。本章介绍了动物模型的糖和脂肪暴食，允许这些行为及其伴随的生理效应的详细分析。暴饮暴食的模型已成功地用于在大鼠中引起依赖的行为和神经化学迹象;例如，阿片样戒断指数、戒断后摄入量增加、与滥用药物的交叉致敏以及反复暴饮暴食后丘脑核中多巴胺的反复释放。使用脂肪暴饮暴食模型的研究表明，它可以产生一些，但不是所有的依赖迹象，这些迹象与糖暴饮暴食有关，以及增加体重，可能导致肥胖。
Binge eating is a behavior that occurs in some eating disorders, as well as in obesity and in nonclinical populations. Both sugars and fats are readily consumed by human beings and are common components of binges. This chapter describes animal models of sugar and fat bingeing, which allow for a detailed analysis of these behaviors and their concomitant physiological effects. The model of sugar bingeing has been used successfully to elicit behavioral and neurochemical signs of dependence in rats; e.g., indices of opiate-like withdrawal, increased intake after abstinence, cross-sensitization with drugs of abuse, and the repeated release of dopamine in the nucleus accumbens following repeated bingeing. Studies using the model of fat bingeing suggest that it can produce some, but not all, of the signs of dependence that are seen with sugar binge eating, as well as increase body weight, potentially leading to obesity.