Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria.
Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria.
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DOI：
10.1042/bst0391051
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发表时间：
2011-08
影响因子：
3.9
通讯作者：
Di YP
中科院分区：
文献类型：
--
作者：
Di YP
腭、肺和鼻上皮癌相关（PLC-NA）最初指的是一个基因，但现在已经扩展到代表一个基因家族，该家族由许多具有肽序列同源性和预测结构相似性的基因组成。PLUNC样蛋白显示与BPI的序列同源性，BPI是由多形核白细胞的前体产生的456个残基的阳离子蛋白，其已被证明具有杀菌和LPS结合活性。人PLG也被称为肺特异性X蛋白（LUNX）、鼻咽癌相关蛋白（NASG）和上呼吸道分泌蛋白（SPURT）。最初命名为PLC 1的基因现在被认为是SPLUNC 1。其基因产物SPLUNC 1是一种分泌性蛋白，在上呼吸道的表面上皮细胞和肺、头颈部的分泌腺中大量表达。SPLUNC 1在先天免疫中的功能作用已经被提出，但尚未明确定义。本文将描述支持SPLUNC 1在革兰氏阴性菌诱导的呼吸道感染中的抗菌和抗炎功能的最新研究结果。
Palate, lung, and nasal epithelium carcinoma associated (PLUNC) originally referred to one gene, but now has been extended to represent a gene family that consists of a number of genes with peptide sequence homologies and predicted structural similarities. PLUNC-like proteins display sequence homology to BPI, a 456-residue cationic protein produced by precursors of polymorphonuclear leukocytes, that has been shown to possess both bactericidal and LPS binding activities. The human PLUNC is also known as lung specific X protein (LUNX), nasopharyngeal carcinoma-related protein (NASG), and secretory protein in upper respiratory tracts (SPURT). The gene originally named PLUNC is now recognized as SPLUNC1. Its gene product SPLUNC1 is a secretory protein that is abundantly expressed in cells of the surface epithelium in the upper respiratory tracts and secretory glands in lung, and head and neck region. The functional role of SPLUNC1 in innate immunity has been suggested but not clearly defined. This paper will describe recent findings that support antimicrobial and anti-inflammatory functions of SPLUNC1 in gram negative bacteria induced respiratory infection.