Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD
Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD
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DOI：
10.1191/0748233701th096oa
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发表时间：
2001-05-01
影响因子：
1.9
通讯作者：
Nolan, CJ
中科院分区：
文献类型：
--
作者：
Johnson, ES;Shorter, C;Nolan, CJ
我们测量了澳大利亚维多利亚州37名喷洒2，4，5-三氯苯氧乙酸（2，4，5-T）的男性当前血清激素和2，3，7，8-四氯二苯并-对-二恶英（TCDD）浓度。在所有分析中，TCDD水平始终与催乳素水平呈显着负相关。在相关性分析中，TCDD水平与三碘甲状腺原氨酸（T3）、促甲状腺激素（TSH）和睾酮水平呈负相关，与胰高血糖素水平呈正相关。这些喷雾器中的平均血清TCDD浓度在2.6和8.1万亿分之一（ppt）之间。由于这种TCDD水平在美国等国家的普通人群中很常见，因此研究结果可能表明，普通人群中TCDD的背景水平可能会对激素水平产生影响。调查结果是初步的，需要复制，以评估其全面的公共卫生意义。
We measured current serum hormone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations in 37 men who sprayed 2,4,5 trichlorophenoxyacetic acid (2,4,5-T) in the State of Victoria, Australia. TCDD levels were consistently significantly inversely related to prolactin levels in all analyses. In correlation analyses, TCDD levels were also inversely related to triiodothyronine (T3), thyroid-stimulating hormone (TSH), and testosterone levels, and positively associated with glucagon levels. The mean serum TCDD concentration in these sprayers was between 2.6 and 8.1 parts per trillion (ppt). Since such TCDD levels are commonly found in the general population in countries such as the US, the results could suggest that background levels of TCDD in the general population could have an effect on hormone levels. The findings are preliminary and need to be replicated in order to evaluate their full public health significance.