Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients
Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients
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DOI：
10.2967/jnumed.112.115188
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发表时间：
2013-04-01
影响因子：
9.3
通讯作者：
de Bree, Remco
中科院分区：
文献类型：
--
作者：
Heuveling, Derrek A.;van Schie, Annelies;de Bree, Remco
传统的成像技术，如平面淋巴结造影和SPECT/CT，术前前哨淋巴结（SN）的识别可能是困难的，当SN附近的原发性肿瘤，如在口底癌的情况下。PET/CT淋巴管造影可改善此类SN的检测和定位。研究方法：在这项研究中，使用Zr-89-纳米胶体白蛋白PET/CT淋巴管造影的临床可行性进行了评估5例口腔癌患者。在瘤周注射Zr-89-纳米胶体白蛋白后进行PET/CT淋巴结造影。在注射Zr-89-nano-colloidal albumin后7-9 d对相同患者进行常规SN程序，包括使用Tc-99 m-nano-colloidal albumin的SPECT/CT。结果：PET/CT和SPECT/CT上放射性胶体分布的比较显示了相同的引流模式。此外，PET/CT能够识别原发肿瘤附近的其他病灶。结论：这项关于SN检测的初步PET/CT研究表明，使用Zr-89-纳米胶体白蛋白进行淋巴结造影是可行的。
With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/CT lymphoscintigraphy using Zr-89-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of Zr-89-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using Tc-99m-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of Zr-89-nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using Zr-89-nanocolloidal albumin is feasible.