Extra-pituitary prolactin (PRL) and prolactin-like protein (PRL-L) in chickens and zebrafish
Extra-pituitary prolactin (PRL) and prolactin-like protein (PRL-L) in chickens and zebrafish
复制标题
鸡和斑马鱼的垂体外催乳素 (PRL) 和催乳素样蛋白 (PRL-L)
DOI：
10.1016/j.ygcen.2015.02.001
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发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Wang, Yajun
中科院分区：
文献类型：
--
作者：
Bu, Guixian;Liang, Xiaomeng;Wang, Yajun
在脊椎动物中，催乳素（prolactin，PRL）主要由垂体催乳细胞合成和释放，通过激活PRL受体（prolactin receptor，PRLR）参与水电解质平衡、生殖、生长发育、代谢、免疫调节和行为等多种生理过程。然而，越来越多的证据表明，PRL和新发现的PRL受体的新型配体“催乳素样蛋白（PRL-L β）”也在非哺乳类脊椎动物的脑、皮肤、卵巢和睾丸等多种垂体外组织中表达。本文综述了本实验室和其他实验室近年来对鸡（Gallus gallus）和斑马鱼（Danio rerio）的PRL和PRL-L的结构、生物学活性以及垂体外表达的研究进展，并简要讨论了它们在非哺乳类脊椎动物中潜在的旁分泌/自分泌作用，这可能促使我们重新思考以前仅归因于垂体PRL的广泛的PRL作用。(C)2015 Elsevier Inc. All rights reserved.
It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior. However, there is increasing evidence showing that PRL and the newly identified 'prolactin-like protein (PRL-L)', a novel ligand of PRL receptor, are also expressed in a variety of extra-pituitary tissues, such as the brain, skin, ovary, and testes in non-mammalian vertebrates. In this brief review, we summarize the recent research progress on the structure, biological activities, and extra-pituitary expression of PRL and PRL-L in chickens (Gallus gallus) and zebrafish (Danio rerio) from our and other laboratories and briefly discuss their potential paracrine/autocrine roles in non-mammalian vertebrates, which may promote us to rethink the broad spectrum of PRL actions previously attributed to pituitary PRL only. (C) 2015 Elsevier Inc. All rights reserved.