Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
复制标题
DOI：
10.1016/s0968-0896(01)00180-8
复制
发表时间：
2001-12
影响因子：
3.5
通讯作者：
A. Pathak;V. Pathak;J. Maddry;W. J. Suling;S. Gurcha;G. Besra;R. Reynolds
中科院分区：
文献类型：
--
作者：
A. Pathak;V. Pathak;J. Maddry;W. J. Suling;S. Gurcha;G. Besra;R. Reynolds
多药耐药结核分枝杆菌（MTB）在世界范围内的出现，促使人们寻找新的、更安全、更有效的抗结核药物。在研究分枝杆菌细胞壁多糖生物合成的基础上，合成了5-O-（α-d-阿拉伯呋喃糖基）-α-d-阿拉伯呋喃糖苷辛酯类似物，并对其作为分枝杆菌抑制剂的活性进行了评价。结核病和鸟分枝杆菌。无细胞测定系统已被用于评价这些二糖作为分枝杆菌阿拉伯糖基转移酶活性的底物。
The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(α-d-arabinofuranosyl)-α-d-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity.