Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different?
Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different?
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DOI：
10.1007/s10803-020-04408-4
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发表时间：
2020-07-08
影响因子：
3.9
通讯作者：
Parellada, M.
中科院分区：
文献类型：
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作者：
Boada, L.;Lahera, G.;Parellada, M.
社会认知障碍是精神分裂症谱系障碍（SSD）和自闭症谱系障碍（ASD）的核心共同表型。本研究通过四种不同的工具对 147 名 ASD 或 SSD 患者以及健康对照者的社会认知表现进行了比较。我们发现，两个临床组的表现相似，但在所有社会认知任务中都比健康对照组表现更差。只有社会认知评估（MASC）测试的电影表现与年龄和智力无关。按比例来说，对照组的个体比两个患者组犯的心理过度错误显着更多，并且比 SSD 患者犯的心理不足错误更少。 AUC 分析表明 MASC 是区分临床组和对照组的最佳工具。多变量分析显示，阴性症状严重程度是社会认知缺陷与整体功能不良之间关联的潜在中介因素。
Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Only performance on the Movie for the Assessment of Social Cognition (MASC) test was independent of age and intelligence. Proportionately, individuals in the control group made significantly more overmentalization errors than both patients group did and made fewer undermentalization errors than patients with SSD did. AUC analyses showed that the MASC was the instrument that best discriminated between the clinical and control groups. Multivariate analysis showed negative symptom severity as a potential mediator of the association between social cognition deficit and poor global functioning.