Mathematical properties of Fst between admixed populations and their parental source populations
Mathematical properties of Fst between admixed populations and their parental source populations
复制标题
DOI：
10.1016/j.tpb.2011.05.003
复制
发表时间：
2011-11-01
影响因子：
1.4
通讯作者：
Rosenberg, Noah A.
中科院分区：
文献类型：
--
作者：
Boca, Simina M.;Rosenberg, Noah A.
我们考虑了混合群体与其亲本源群体之间遗传分化的f - 1测度的性质。在任意一组亲本群体中混合的所有可能群体中，我们证明了当混合群体与其他源群体距离最远时，混合群体与特定源群体之间的F-st值最大。对于只有两个亲本群体的情况，作为混合分数的函数，我们进一步证明了这个F-st值是单调的和凸的，因此F-st是关于混合分数的信息。我们使用人类种群遗传数据来说明我们的结果，展示它们如何提供一个框架来解释混合种群中的F-st特征。(C) 2011爱思唯尔公司版权所有。
We consider the properties of the F-st measure of genetic divergence between an admixed population and its parental source populations. Among all possible populations admixed among an arbitrary set of parental populations, we show that the value of F-st between an admixed population and a specific source population is maximized when the admixed population is simply the most distant of the other source populations. For the case with only two parental populations, as a function of the admixture fraction, we further demonstrate that this F-st value is monotonic and convex, so that F-st is informative about the admixture fraction. We illustrate our results using example human population-genetic data, showing how they provide a framework in which to interpret the features of F-st in admixed populations. (C) 2011 Elsevier Inc. All rights reserved.