Sleep Duration and Biomarkers of Inflammation
Sleep Duration and Biomarkers of Inflammation
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DOI：
10.1093/sleep/32.2.200
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发表时间：
2009-02-01
期刊：
影响因子：
5.6
通讯作者：
Redline, Susan
中科院分区：
文献类型：
--
作者：
Patel, Sanjay R.;Zhu, Xiaobei;Redline, Susan
简介：睡眠时间过长与不良健康结果有关。其机制尚不清楚，但可能与炎症增加有关。我们试图评估睡眠持续时间和炎症生物标志物之间的关联。方法：来自克利夫兰家庭研究的总共 614 名个体完成了有关睡眠习惯的问卷调查并接受了多导睡眠图检查。检测早晨空腹血液样本中的 5 种炎症细胞因子。 结果：在该队列中，基于自我报告的平均 (SD) 习惯性睡眠持续时间为 7.6 (1.6) 小时，采血前一天晚上通过多导睡眠图 (PSG) 测得的平均睡眠持续时间为 6.2 (1.3) 小时。调整肥胖和呼吸暂停严重程度后，习惯性睡眠时间每增加一小时，C 反应蛋白 (CRP) 水平就会增加 8% (P = 0.004)，白介素 6 (IL-6) 水平就会增加 7% (P = 0.0003)。这些关联与自我报告的困倦无关。相反，PSG 睡眠时间与肿瘤坏死因子 α (TNF α) 水平呈负相关。睡眠时间每减少一小时，TNFa 水平平均增加 8% (P = 0.02)。睡眠时间与 IL-1 或 IL-10 无关。结论：习惯性睡眠时间的增加与 CRP 和 IL-6 的升高相关，而 PSG 睡眠时间的减少与 TNFa 水平的升高相关。促炎途径的激活可能代表极端睡眠习惯影响健康的机制。
Introduction: Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers.Methods: A total of 614 individuals from the Cleveland Family Study completed questionnaires about sleep habits and underwent polysomnography. A morning fasting blood sample was assayed for 5 inflammatory cytokines.Results: In this cohort, mean (SD) habitual sleep duration based on self-report was 7.6 (1.6) h and mean sleep duration by polysomnography (PSG) on the night prior to blood sampling was 6.2 (1.3) h. After adjusting for obesity and apnea severity, each additional hour of habitual sleep duration was associated with an 8% increase in C-reactive protein (CRP) levels (P = 0.004) and 7% increase in interleukin-6 (IL-6) levels (P = 0.0003). These associations were independent of self-reported sleepiness. In contrast, PSG sleep duration was inversely associated with tumor necrosis factor alpha (TNF alpha) levels. For each hour reduction in sleep, TNFa levels increased by 8% on average (P = 0.02). Sleep duration was not associated with IL-1 or IL-10.Conclusions: Increases in habitual sleep durations are associated with elevations in CRP and IL-6 while reduced PSG sleep duration is associated with elevated TNFa levels. Activation of pro-inflammatory pathways may represent a mechanism by which extreme sleep habits affect health.