Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression.
Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression.
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DOI：
10.3390/ijms23052741
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发表时间：
2022-03-01
影响因子：
5.6
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Kumar S;Kumar V;Li W;Kim J
Ventx家族是ANTP超家族的一个亚家族，属于NK样(NKL)亚类。Ventx是一种同源框转录因子，具有DNA相互作用结构域，在脊椎动物中进化上是保守的。它已经在非洲爪哇、斑马鱼和人类身上进行了广泛的研究。Ventx家族包含广泛参与脊椎动物胚胎发育和肿瘤发生的转录抑制因子。一些研究已经证明，Ventx家族抑制非洲爪哇和斑马鱼的背部中胚层形成、神经诱导和头部形成。此外，Ventx2.2与Nanog和Barx1的功能相似，导致脊椎动物的多能性和神经脊迁移。其中，Ventx蛋白是人类Ventx家族的同源基因。研究表明，人类Ventx与髓系细胞分化和急性髓系白血病密切相关。讨论了Ventx家族抑制在人类抗癌进展中的治疗潜力。此外，我们还简要讨论了非洲爪哇的基因组进化、基因复制、假异源四倍体和同源盒家族。
The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and humans. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia. The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in Xenopus.