Surface Composition and Morphology of Particles Dried Individually and by Spray Drying
Surface Composition and Morphology of Particles Dried Individually and by Spray Drying
复制标题
单独干燥和喷雾干燥颗粒的表面组成和形态
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
B. Bergenståhl
中科院分区：
文献类型：
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作者：
M. Nuzzo;A. Millqvist;J. Sloth;B. Bergenståhl
这项研究调查了喷雾干燥颗粒的形态如何与配方和配方中各组分的性质有关。此外，还讨论了在实验室规模的喷雾干燥器中比较悬浮干燥的单颗粒和喷雾干燥的颗粒的尺度效应。干燥动力学分析仪TM在模拟喷雾干燥条件下从悬浮液滴中产生单个颗粒。分析了一系列表面活性聚合物(牛血清白蛋白、羟丙甲基纤维素和三嵌段共聚物泊洛沙姆)与乳糖在溶液中的动态表面性质，并用低真空扫描电子显微镜和X射线光电子能谱分析了它们对粒子形态和表面组成的影响。喷雾干燥得到的形貌在单颗粒干燥中得以再现。表面组成也相似，但与喷雾干燥颗粒相比，单个颗粒表面的表面活性物质水平更高。此外，动态表面张力估测的表面活性化合物在液滴表面的吸附速率是估算不同干燥尺度下表面组成的重要参数。颗粒形态主要由料液的表面流变性决定，其次由表面组成决定。
This study investigates how the morphology of spray-dried particles is related to the formulation and properties of the components in the formulation. Further, the scale effects in comparisons of levitation-dried single particles and spray-dried particles in a lab-scale spray dryer have been addressed. The Drying Kinetics AnalyzerTM generates single particles from a levitated drop under simulated spray-drying conditions. A set of surface-active polymers (bovine serum albumin, hydroxypropyl methyl cellulose, and triblock co-polymer Poloxamer), in combination with lactose, were analyzed for their dynamic surface properties in solution, and their effect on particle morphology and surface composition were determined by low-vacuum SEM and XPS analyses. The morphology obtained in spray drying was reproduced in the single-particle drying. The surface compositions were also similar, but higher levels of surface-active materials were found at the surface of the single particles as compared to the spray-dried particles. Further, the adsorption rate of surface-active compounds at the drop surface estimated by dynamic surface tension was found to be an important parameter to estimate the surface composition at different drying scales. The particle morphology was primarily determined by the surface rheological properties of the feed solution and, to a lesser extent, by the surface composition.