Spaying-induced coat changes:: the role of gonadotropins, GnRH and GnRH treatment on the hair cycle of female dogs
Spaying-induced coat changes:: the role of gonadotropins, GnRH and GnRH treatment on the hair cycle of female dogs
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DOI：
10.1111/j.1365-3164.2008.00652.x
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发表时间：
2008-04-01
影响因子：
1.4
通讯作者：
Arnold, Susi
中科院分区：
文献类型：
--
作者：
Reichler, Iris Margaret;Welle, Monika;Arnold, Susi
虽然喷涂可以导致狗的毛质的变化，但喷涂对毛发生长周期的影响从未被描述过。本研究旨在探讨喷雾和促性腺激素释放激素（GnRH）处理对犬毛被、毛囊周期阶段、血浆促性腺激素浓度以及毛囊促性腺激素（LH）和GnRH受体mRNA转录的影响。15只雌性犬在治疗前和治疗后1年进行检查，24只切除犬在GnRH治疗前和治疗后进行检查。喷药导致血浆促性腺激素浓度升高，毛囊的生长期和休止期比例增加，但只有20%的狗发生了被毛变化。LH和GnRH受体mRNA转录无差异。GnRH治疗导致79%的患者血浆促性腺激素浓度降低，皮肤变化改善。这与生长期毛囊的增加有关，而生长期与休止期的比例没有变化。本研究表明，喷雾对毛囊的生长期和休止期比例有影响。喷涂诱导的皮毛变化与生长期：休止期比例无关。GnRH治疗降低了一些狗的促性腺激素浓度，逆转了被毛的变化，但除了增加毛囊的数量外，对毛发生长周期没有影响。血浆LH浓度与生长期：休止期比值呈弱正相关；然而，我们的数据并没有表明受体介导的激素对毛囊有直接的影响。目前的研究没有确定喷涂诱导的皮毛变化的病理机制。
Although spaying can result in qualitative hair coat changes in dogs, the influence of spaying on the hair growth cycle has never been described. The study aims were to examine the effect of spaying and gonadotropin-releasing hormone (GnRH) treatment on canine hair coat, cycle stages of hair follicles, plasma gonadotropin concentrations and mRNA transcription of luteinizing hormone (LH) and GnRH receptors in hair follicles. Fifteen female dogs were examined before and 1 year after spaying and 24 spayed dogs before and after GnRH treatment. Spaying resulted in increased plasma gonadotropin concentrations and increased anagen : telogen ratio of hair follicles, but only 20% of the dogs developed coat changes. No differences were found in mRNA transcription of LH and GnRH receptors. GnRH treatment resulted in reduced plasma gonadotropin concentrations and improvement of coat changes in 79% of patients. This was associated with an increase in catagen hair follicles without changes in the anagen : telogen ratio. The present study demonstrated that spaying had an effect on the anagen : telogen ratio of hair follicles. Spaying-induced coat changes did not correlate with the anagen : telogen ratio. GnRH treatment reduced gonadotropin concentrations and reversed coat changes in some dogs, but had no effect on the hair growth cycle other than increasing the number of catagen hair follicles. A weak positive correlation between the plasma LH concentration and the anagen : telogen ratio was noted; however, our data did not suggest a direct receptor-mediated hormonal effect on the hair follicle. The present study did not identify the pathomechanism of spaying-induced coat changes.