Endothelial differentiation: molecular mechanisms of specification and heterogeneity.
Endothelial differentiation: molecular mechanisms of specification and heterogeneity.
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DOI：
10.1161/atvbaha.111.228999
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Hamik A
中科院分区：
文献类型：
--
作者：
Atkins GB;Jain MK;Hamik A
复杂多样的维管系统是高等生物生存所必需的。血管发育的过程受到高度调节，涉及血管的从头形成（血管发生），随后是原始血管系统的扩张和重塑（血管生成），最终在成熟血管系统中发现的内皮表型的分化中达到高潮。在过去的十年中，在了解内皮细胞发育和分化的分子调控方面取得了重大进展。内皮细胞的发展，特别是在血管发生和血管生成过程中发挥作用的机制，是讨论在姐妹审查这篇文章。本文综述了内皮细胞分化的关键途径，重点介绍了内皮细胞特异性和异质性的主要分子机制。
A complex and diverse vascular system is requisite for the survival of higher organisms. The process of vascular development is highly regulated involving the de novo formation of vessels (vasculogenesis), followed by expansion and remodeling of the primitive vasculature (angiogenesis), culminating in differentiation of endothelial phenotypes as found in the mature vascular system. Over the last decade significant advances have been accomplished in understanding the molecular regulation of endothelial cell development and differentiation. Endothelial development, in particular the mechanisms in play during vasculogenesis and angiogenesis, is discussed in a sister review to this article. This review highlights the key pathways governing in endothelial differentiation with a focus on the major molecular mechanisms of endothelial specification and heterogeneity.