Phenotyping Neurodegeneration in Human iPSCs.
Phenotyping Neurodegeneration in Human iPSCs.
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DOI：
10.1146/annurev-biodatasci-092820-025214
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发表时间：
2021-07-20
期刊：
影响因子：
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Induced pluripotent stem cell (iPSC) technology holds promise for modeling neurodegenerative diseases. Traditional approaches for disease modeling using animal and cellular models require knowledge of disease mutations. However, many patients with neurodegenerative diseases do not have a known genetic cause. iPSCs offer a way to generate patient-specific models and study pathways of dysfunction in an in vitro setting, to understand the causes and subtypes of neurodegeneration. Furthermore, iPSC-based models can be used to search for candidate therapeutics using high throughput screening. Here we review how iPSC-based models are currently being used to further our understanding about neurodegenerative diseases and discuss their challenges and future directions.
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DOI：
10.1016/j.mcn.2013.07.007
发表时间：
2013-09
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Burkhardt MF;Martinez FJ;Wright S;Ramos C;Volfson D;Mason M;Garnes J;Dang V;Lievers J;Shoukat-Mumtaz U;Martinez R;Gai H;Blake R;Vaisberg E;Grskovic M;Johnson C;Irion S;Bright J;Cooper B;Nguyen L;Griswold-Prenner I;Javaherian A
通讯作者：
Javaherian A
影响因子：
25
作者：
Gan L;Cookson MR;Petrucelli L;La Spada AR
通讯作者：
La Spada AR
影响因子：
11
作者：
Gonzalez C;Armijo E;Bravo-Alegria J;Becerra-Calixto A;Mays CE;Soto C
通讯作者：
Soto C
影响因子：
12.6
作者：
Cheng, Xiao-Yu;Biswas, Sangita;Deng, Wen-Bin
通讯作者：
Deng, Wen-Bin
影响因子：
16.2
作者：
Coyne AN;Zaepfel BL;Hayes L;Fitchman B;Salzberg Y;Luo EC;Bowen K;Trost H;Aigner S;Rigo F;Yeo GW;Harel A;Svendsen CN;Sareen D;Rothstein JD
通讯作者：
Rothstein JD