Snoring, Daytime Sleepiness, and Incident Cardiovascular Disease in The Health, Aging, and Body Composition Study
Snoring, Daytime Sleepiness, and Incident Cardiovascular Disease in The Health, Aging, and Body Composition Study
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DOI：
10.5665/sleep.3140
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发表时间：
2013-11-01
期刊：
影响因子：
5.6
通讯作者：
Pahor, Marco
中科院分区：
文献类型：
--
作者：
Endeshaw, Yohannes;Rice, Thomas B.;Pahor, Marco
目的：研究打鼾症与心血管疾病(CVD)的关系。设计、设置和参与者：这是一项前瞻性研究，对社区居住的老年人进行基线评估，平均随访9.9年。测量：收集研究参与者的鼾声、日间嗜睡以及人口统计学和临床特征的基线数据，并每6个月对参与者进行平均9.9年的随访。根据鼾症和嗜睡状态分为4组：(1)无鼾症，无嗜睡；(2)无鼾症，嗜睡；(3)鼾症，无嗜睡；(4)鼾症，嗜睡。事件心血管疾病被定义为在随访期内因心肌梗死、心绞痛或充血性心力衰竭而住院过夜的诊断。结果：共有2320名参与者，基线年龄为73.6(2.9)岁，全部进入分析。52%是女性，58%是白人。共有543名参与者在随访期内发生了心血管事件。在调整人口学和临床混杂因素后，报告打鼾者发生心血管事件的风险比显著增加(HR=1.46[1.03-2.08]，P=0.035)。结论：研究结果提示，老年人中自我报告的打鼾症和日间嗜睡状态与未来心血管疾病的风险增加有关。
Objectives: To examine the association between snoring and incident cardiovascular disease (CVD).Design, Settings, and Participants: This is a prospective study in which community dwelling older adults were evaluated at baseline, and followed up for an average of 9.9 years.Measurements: Data on snoring, daytime sleepiness, as well as demographic and clinical characteristics of study participants was collected at baseline, and participants were followed up every six months for an average of 9.9 years. Based on snoring and sleepiness status, 4 groups of participants were created: (1) No Snoring, No Sleepiness; (2) No Snoring, Sleepiness; (3) Snoring, No Sleepiness; (4) Snoring, Sleepiness. Incident CVD was defined as a diagnosis of myocardial infarction, angina pectoris, or congestive heart failure that resulted in overnight hospitalization during the follow-up period. Cox proportional hazard was used to estimate the risk of incident cardiovascular disease during follow-up by baseline snoring and sleepiness status.Results: A total of 2,320 participants with a mean age of 73.6 (2.9) years at baseline were included in the analysis. Fifty-two percent were women, and 58% were white. A total of 543 participants developed CVD events during the follow-up period. Participants who reported snoring associated with daytime sleepiness had significantly increased hazard ratio for CVD events (HR = 1.46 [1.03-2.08], P = 0.035) after adjusting for demographic and clinical confounding factors.Conclusion: The results suggest that self-reported snoring and daytime sleepiness status are associated with an increased risk of future cardiovascular disease among older adults.