Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System.
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DOI：
10.3390/ijms18061243
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发表时间：
2017-06-09
影响因子：
5.6
通讯作者：
Chu CY
中科院分区：
文献类型：
--
作者：
Cho YT;Yang CW;Chu CY
药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征是一种严重的多器官超敏反应，主要由遗传易感性患者中有限数量的诱发药物引起。DRESS综合征患者具有特征性但可变的临床和病理特征。人类疱疹病毒（HHV），特别是HHV-6的重新激活是该疾病的标志。抗病毒免疫反应与药物超敏反应交织在一起，使疾病更加复杂和持久。近年来，新兴的研究已经更清楚地概述了这种疾病，尽管一些重要的问题仍然没有解决。本文就DRESS综合征的临床表现、组织病理学特征、发病机制及治疗方法进行综述。
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syndrome present with characteristic but variable clinical and pathological features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the hallmark of the disease. Anti-viral immune responses intertwined with drug hypersensitivity make the disease more complicated and protracted. In recent years, emerging studies have outlined the disease more clearly, though several important questions remain unresolved. In this review, we provide an overview of DRESS syndrome, including clinical presentations, histopathological features, pathomechanisms, and treatments.