Gold Compounds and the Anticancer Immune Response.
Gold Compounds and the Anticancer Immune Response.
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金化合物与抗癌免疫反应
DOI：
10.3389/fphar.2021.739481
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发表时间：
2021
影响因子：
5.6
通讯作者：
Wei S
中科院分区：
文献类型：
--
作者：
Zhou L;Liu H;Liu K;Wei S
金化合物不仅对肿瘤的细胞毒性作用进行了深入研究，而且还与癌症免疫系统相互作用。免疫系统利用先天和适应性机制来防御病原体并防止恶性转化。通过体内和体外实验，金化合物与激活的免疫系统的联合作用在癌症治疗中显示出有希望的结果。已知金化合物可诱导先天免疫反应；然而，这些反应可能有助于适应性免疫反应。金化合物起着主要半抗原的作用，在先天免疫中协同作用。金化合物通过诱导 CRT、ATP、HMGB1、HSP 和 NKG2D 的释放来增强免疫原性，支持癌细胞抗原性并促进抗肿瘤免疫反应。金化合物影响多种免疫细胞（包括抑制调节性T细胞），抑制骨髓源性抑制细胞，增强树突状细胞的功能和数量。金纳米粒子（AuNPs）具有提高免疫治疗效果并减少治疗过程的毒性和副作用的潜力。因此，AuNPs 为探索抗癌金化合物和免疫治疗干预的结合提供了理想的机会。
Gold compounds are not only well-explored for cytotoxic effects on tumors, but are also known to interact with the cancer immune system. The immune system deploys innate and adaptive mechanisms to protect against pathogens and prevent malignant transformation. The combined action of gold compounds with the activated immune system has shown promising results in cancer therapy through in vivo and in vitro experiments. Gold compounds are known to induce innate immune responses; however, these responses may contribute to adaptive immune responses. Gold compounds play the role of a major hapten that acts synergistically in innate immunity. Gold compounds support cancer cell antigenicity and promote anti-tumor immune response by inducing the release of CRT, ATP, HMGB1, HSP, and NKG2D to enhance immunogenicity. Gold compounds affect various immune cells (including suppressor regulatory T cells), inhibit myeloid derived suppressor cells, and enhance the function and number of dendritic cells. Gold nanoparticles (AuNPs) have potential for improving the effect of immunotherapy and reducing the toxicity and side effects of the treatment process. Thus, AuNPs provide an ideal opportunity for exploring the combination of anticancer gold compounds and immunotherapeutic interventions.
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具有免疫刺激活性的聚腺嘌呤尾 CpG 寡核苷酸-金纳米颗粒纳米缀合物的自组装
影响因子：
13.3
作者：
Chen, Nan;Wei, Min;Huang, Qing
通讯作者：
Huang, Qing
DOI：
10.2174/1871520615666150129211440
发表时间：
2015-01-01
影响因子：
2.8
作者：
Garcia-Moreno, Elena;Gascon, Sonia;Laguna, Mariano
通讯作者：
Laguna, Mariano
DOI：
10.1007/s00775-018-1546-8
发表时间：
2018-05
期刊：
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
影响因子：
--
作者：
Elie BT;Pechenyy Y;Uddin F;Contel M
通讯作者：
Contel M
影响因子：
7.3
作者：
Bräunlein E;Krackhardt AM
通讯作者：
Krackhardt AM
影响因子：
19
作者：
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通讯作者：
Tian F