The role of the myofibroblast in Dupuytren's contracture.
The role of the myofibroblast in Dupuytren's contracture.
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肌成纤维细胞在掌腱膜挛缩中的作用。
DOI：
10.1001/archderm.1980.01640310077026
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发表时间：
1980
影响因子：
--
通讯作者：
R. Odom
中科院分区：
文献类型：
--
作者：
W. James;R. Odom
一个病例报告的Dupuytren的挛缩说明了功能和光镜和电镜特征的肌成纤维细胞。肌成纤维细胞现在与越来越多的疾病有关，并且被认为是成纤维细胞的形态和功能变体，其显示平滑肌细胞的典型变化。它的存在可能是怀疑由光学显微镜，但其超微结构是特征。其独特的电子显微镜特征是细胞质中类似于平滑肌的纤维系统，指示收缩的核变形，以及提供与邻近细胞和基质附着的表面膜分化。
A case report of Dupuytren's contracture illustrates the functional and light and electron microscopic characteristics of the myofibroblast. The myofibroblast is now associated with an increasing number of diseases, and is believed to be a morphologic and functional variant of the fibroblast, which shows changes typical of smooth-muscle cells. Its presence may be suspected by light microscopy, but its ultrastructure is characteristic. Its distinctive electron microscopic features are a fibrillar system in the cytoplasm similar to that of a smooth muscle, nuclear deformations indicative of contraction, and surface membrane differentiations that provide attachment to neighboring cells and stroma.