Grading of corneal and conjunctival staining in the context of other dry eye tests
Grading of corneal and conjunctival staining in the context of other dry eye tests
复制标题
DOI：
10.1097/00003226-200310000-00008
复制
发表时间：
2003-10-01
期刊：
影响因子：
2.8
通讯作者：
Smith, JA
中科院分区：
文献类型：
--
作者：
Bron, AJ;Evans, VE;Smith, JA
目的：描述用于干眼症眼表染色分级的牛津方案，并讨论使用各种染料和滤光片进行染色检测的优化。此外，提出一个序列的测试干眼diagnosis.Methods：角膜和结膜染色的分级描述，使用牛津计划，包括生物显微镜，光学过滤器，照明条件，和特点和滴注技术用于，选定的临床染料。标记为A-E的一系列图，按照严重程度增加的顺序，再现了干眼中遇到的染色模式，用作对患者中观察到的染色程度进行分级的指导。在每个图中观察到的染色量（由点状点表示）在图B至E之间增加0.5个点的对数。描述了活体染料荧光素、丽丝胺绿色和孟加拉玫瑰红的使用;荧光素和丽丝胺绿色与适当的吸收过滤器结合使用，建议用于临床试验。染色的其他诊断tests.Conclusions的顺序有关的放置：角膜和结膜染色的监测和评估，可以大大提高使用的分级尺度，控制滴注染料，和标准的评价技术。这在临床试验中特别有益，其中眼表染色通常用作结果测量。
Purpose: To describe the Oxford Scheme for grading ocular surface staining in dry eye and to discuss optimization of stain detection using various dyes and filters. Also, to propose a sequence of testing for dry eye diagnosis.Methods: The grading of corneal and conjunctival staining is described, using the Oxford Scheme, including biomicroscopy, optical filters, illumination conditions, and the characteristics of and instillation techniques used for, selected clinical dyes.Results: A series of panels, labeled A-E, in order of increasing severity, reproducing the staining patterns encountered in dry eye, are used as a guide to grade the degree of staining seen in the patient. The amount of staining seen in each panel, represented by punctate dots, increases by 0.5 of the log of the number of dots between panels B to E. The use of the vital dyes fluorescein, lissamine green, and rose Bengal is described; fluorescein and lissamine green, used in conjunction with appropriate absorption filters, are recommended for use in clinical trials. The placement of staining in relation to the sequence of other diagnostic tests is discussed.Conclusions: The monitoring and assessment of corneal and conjunctival staining can be greatly enhanced by the use of a grading scale, controlled instillation of dyes, and standard evaluation techniques. This is of particular benefit in clinical trials, where ocular surface staining is commonly employed as an outcome measure.