The use of continuous IV sedation is associated with prolongation of mechanical ventilation
The use of continuous IV sedation is associated with prolongation of mechanical ventilation
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DOI：
10.1378/chest.114.2.541
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发表时间：
1998-08-01
期刊：
影响因子：
9.6
通讯作者：
Sherman, G
中科院分区：
文献类型：
--
作者：
Kollef, MH;Levy, NT;Sherman, G
研究目的：确定持续静脉镇静的使用是否与机械通气时间的延长有关。设计：前瞻性观察队列研究。地点：巴恩斯-犹太医院内科ICU，一所大学附属的城市教学医院。患者：连续242名需要机械通气的ICU患者。干预：患者监测和数据收集。测量和结果：主要的结果衡量标准是机械通气的时间。次要结果指标包括ICU和住院时间、住院死亡率和获得性器官系统紊乱。93例(38.4%)机械通气患者在插管后接受持续静脉镇静，149例(61.6%)患者在插管后接受静脉注射镇静()或不静脉注射镇静(n=85)。接受持续静脉镇静的患者机械通气时间明显长于未接受持续静脉镇静的患者(185±190h比55.6±75.6h；p
Study objective: To determine whether the use of continuous IV sedation is associated with prolongation of the duration of mechanical ventilation.Design: Prospective observational cohort study.Setting: The medical ICU of Barnes-Jewish Hospital, a university-affiliated urban teaching hospital.Patients: Two hundred forty-two consecutive ICU patients requiring mechanical ventilation.Interventions: Patient surveillance and data collection.Measurements and results: The primary outcome measure was the duration of mechanical ventilation. Secondary outcome measures included ICU and hospital lengths of stay, hospital mortality, and acquired organ system derangements. A total of 93 (38.4%) mechanically ventilated patients received continuous IV sedation while 149 (61.6%) patients received either bolus administration of IV sedation (n=64) or no IV sedation (n=85) following intubation. The duration of mechanical ventilation was significantly longer for patients receiving continuous IV sedation compared with patients not receiving continuous IV sedation (185+/-190 h vs 55.6+/-75.6 h; p