The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei.
The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei.
复制标题
Mel1a 褪黑激素受体基因在人类视交叉上核中表达。
DOI：
10.1097/00001756-199612200-00022
复制
发表时间：
1996
期刊：
影响因子：
1.7
通讯作者：
Reppert,SM
中科院分区：
文献类型：
--
作者：
Weaver,DR;Reppert,SM
THE pineal hormone melatonin influences circadian rhythmicity in many vertebrate species. The circadian effects of melatonin in humans have led to its use to treat jet lag and circadian-based sleep disorders. Melatonin is thought to influence circadian rhythmicity by acting in the suprachiasmatic nuclei (SCN). The recent cloning of two melatonin receptor subtypes with high affinity for melatonin allows molecular analysis of melatonin receptors in human SCN. We report that Mel 1a receptor mRNA is detectable in neonatal human SCN by in situ hybridization. Mel 1b and melatonin-related receptor mRNAs were not detected. The presence of Mel 1a receptor mRNA in human SCN supports the hypothesis that the Mel 1a receptor is responsible for the circadian effects of melatonin in humans.
