Establishment of a Continuous Sonocrystallization Process for Lactose in an Oscillatory Baffled Crystallizer
Establishment of a Continuous Sonocrystallization Process for Lactose in an Oscillatory Baffled Crystallizer
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DOI：
10.1021/acs.oprd.5b00127
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Florence, Alastair J.
中科院分区：
文献类型：
--
作者：
Siddique, Humera;Brown, Cameron J.;Florence, Alastair J.
生产规模的结晶通常是一个鲜为人知的单元操作，在常规设计、优化和控制中，对结晶的第一性原理的理解有限。在本研究中，建立了一种系统的方法来转移现有的间歇式工艺，使其能够在振荡挡板结晶器（OBC）中使用超声波实现连续过程。过程分析技术（PAT）用于了解和监控过程。采用聚焦光束反射测量（FBRM） （Mettler Toledo）和中红外光谱（mid-IR） （ABB）在多孔振荡挡板结晶器（batch - obc）中研究了乳糖超声结晶的动力学和热力学参数。该平台提供了一个理想的模拟混合，流体力学和连续振荡流结晶器（COBC）的操作条件，而只需要有限的材料。对COBC的流体动力学进行了全面表征，以确定在1-5小时的停留时间内实现塞流行为的条件。结果表明，连续结晶在工艺结果和可操作性方面具有显著优势，包括粒径分布（平均粒径）
Crystallization at production scale (>10 kg) is typically a poorly understood unit operation with limited application of first-principles understanding of crystallization to routine design, optimization, and control. In this study, a systematic approach has been established to transfer an existing batch process enabling the implementation of a continuous process in an oscillatory baffled crystallizer (OBC) using ultrasound. Process analytical technology (PAT) was used to understand and monitor the process. Kinetic and thermodynamic parameters have been investigated for lactose sonocrystallization using focused beam reflectance measurement (FBRM) (Mettler Toledo) and mid-infrared spectroscopy (mid-IR) (ABB) in a multiorifice batch oscillatory baffled crystallizer (Batch-OBC). This platform provides an ideal mimic of the mixing, hydrodynamics and operating conditions of the continuous oscillatory flow crystallizer (COBC) while requiring only limited material. Full characterization of the hydrodynamics of the COBC was carried out to identify conditions that deliver plug-flow behavior with residence times of 1-5 h. The results show that continuous crystallization offers significant advantages in terms of process outcomes and operability, including particle size distribution (mean particle size