Impaired olfaction predicts cognitive decline in nondemented older adults
Impaired olfaction predicts cognitive decline in nondemented older adults
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DOI：
10.1159/000048618
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发表时间：
2002-03-01
影响因子：
5.7
通讯作者：
Carmelli, D
中科院分区：
文献类型：
--
作者：
Swan, GE;Carmelli, D
1992 年，对总共 359 名受试者（286 名男性和 73 名女性；1992 年平均年龄 74.3 岁）进行了 12 项简短气味识别测试（R），并在 1992 年和 1996 年对言语学习和记忆、执行控制和整体功能进行了各种测量。基线时有中风病史或认知受损的个体被排除在分析之外。嗅觉功能受损（存在或不存在）与多项语言记忆指数 4.5 年下降幅度较大有关，但与执行控制或整体功能指标的下降无关（在调整基线认知表现、年龄、教育程度、性别和嗅觉困难史后）。嗅觉丧失仍然与言语记忆成分的下降相关，与载脂蛋白 E F,4 状态无关。老年人嗅觉识别受损的预测效用似乎与言语记忆成分的下降有关。版权所有 (C) 2002 S. Karger AG，巴塞尔。
In 1992, the twelve-item Brief Smell Identification Test(R) and, in 1992 and 1996, a variety of measures of verbal learning and memory, executive control, and global function were administered to a total of 359 individuals (286 men and 73 women; mean age in 1992 74.3 years). Individuals with a history of stroke or impaired cognition at baseline were excluded from analyses. Impaired olfactory function (present or absent) was related to a greater 4.5-year decline on several indices of verbal memory, but not to a decline on measures of executive control or of global functioning after adjustment for baseline cognitive performance, age, education, gender, and history of smell difficulties. Olfactory loss remained associated with a decline in components of verbal memory, independently of the apolipoprotein E F,4 status. The predictive utility of impaired smell identification in older adults appears to be specific to a decline in components of verbal memory. Copyright (C) 2002 S. Karger AG, Basel.