Thromboembolisms in atrial fibrillation and heart failure patients with a preserved ejection fraction (HFpEF) compared to those with a reduced ejection fraction (HFrEF)
Thromboembolisms in atrial fibrillation and heart failure patients with a preserved ejection fraction (HFpEF) compared to those with a reduced ejection fraction (HFrEF)
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DOI：
10.1007/s00380-017-1073-5
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发表时间：
2018-04-01
影响因子：
1.5
通讯作者：
Ozaki, Yukio
中科院分区：
文献类型：
--
作者：
Sobue, Yoshihiro;Watanabe, Eiichi;Ozaki, Yukio
心力衰竭（HF）分为三种临床亚型：射血分数正常的HF（HFpEF：EF >= 50%），HF伴中等射血分数（HFmrEF：40 = 75岁（风险比2.14，95%置信区间1.32-3.58，P < 0.01）和血浆B型利钠肽（BNP）水平≥ 341 pg/ml（危险比1.60，95%可信区间1.07-2.39，P < 0.05）与SSE相关。EF不是SSE的独立预测因子（风险比1.01，95%置信区间0.98-1.04，P = 0.51）。AF-HFpEF和AF-HFrEF之间的SSE发生率无显著差异。无论EF如何，HF伴AF患者均应接受抗凝治疗。
Heart failure (HF) is classified into three clinical subtypes: HF with a preserved ejection fraction (HFpEF: EF >= 50%), HF with a mid-range ejection fraction (HFmrEF: 40 = 75 years (hazard ratio 2.14, 95% confidence interval 1.32-3.58, P < 0.01) and the plasma B-type natriuretic peptide (BNP) level >= 341 pg/ml (hazard ratio 1.60, 95% confidence interval 1.07-2.39, P < 0.05) were associated with SSEs. The EF was not an independent predictor of SSEs (hazard ratio 1.01, 95% confidence interval 0.98-1.04, P = 0.51). There were no significant differences in the rates of SSEs between AF-HFpEF and AF-HFrEF. Patients with HF and concomitant AF should be treated with anticoagulants irrespective of EF.