Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium
Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium
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DOI：
10.1016/s0008-6363(01)00437-0
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发表时间：
2002-01-01
影响因子：
10.8
通讯作者：
Janssen, PML
中科院分区：
文献类型：
--
作者：
Hermann, HP;Zeitz, O;Janssen, PML
Background: Pyruvate has been shown to increase contractile function in isolated myocardium and to improve hemodynamics in patients with congestive heart failure. We tested the hypothesis that pyruvate potentiates the inotropic response beta-adrenergic stimulation and to elevated extracellular calcium, since this may be of potential therapeutic value in the clinical setting of acute heart failure in order to circumvent deleterious effects on energy demand as can occur during catecholamine therapy. Methods and Results: We investigated isometrically contracting isolated multicellular muscle preparations from terminal failing human hearth at 37degreesC, pH 7.4, and a stimulation frequency of I Hz. At an extracellular calcium concentration of 1.25 mM, pyruvate ( 10 mM) alone increased developed force (F-dev) from 9.0+/-2.3 to 21.1+/-4.3 mN/mm(2) (n=9, P
