Osteopontin: a bona fide mediator of abdominal aortic aneurysm?
Osteopontin: a bona fide mediator of abdominal aortic aneurysm?
复制标题
骨桥蛋白：腹主动脉瘤的真正介质？
DOI：
10.1161/01.atv.0000258640.30287.7b
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Weintraub,NealL
中科院分区：
文献类型：
--
作者：
Shaheen,Mazen;Weintraub,NealL
骨桥蛋白是一种含有粘附糖蛋白的精氨酸-甘氨酸-天冬氨酸 (RGD)，首先在骨骼中发现，但随后在许多其他组织中检测到，包括牙本质、软骨、肾脏和血管组织。 1–3 它由多种炎症细胞（例如巨噬细胞、T 淋巴细胞、NK 细胞）表达，并且在较小程度上由内皮细胞和平滑肌细胞表达。 RGD 结构域促进骨桥蛋白与各种细胞外基质蛋白（例如 αvß3 整合素和纤连蛋白）的组织结合。此外，骨桥蛋白可能通过 RGD 独立机制与 CD44 结合。在细胞外液中，骨桥蛋白起到细胞因子的作用，其血浆水平在狼疮、类风湿性关节炎和多发性硬化症等自身免疫性疾病中升高。 4 骨桥蛋白的多种生物学作用可能会调节与血管疾病相关的许多过程，包括炎症、细胞粘附、活力、血管生成和钙化（图）。 5, 6 这些作用可能是其在动脉粥样硬化的病理生理学以及调节与糖尿病和慢性肾功能衰竭相关的动脉病中发挥作用的基础（Johnson 等人综述7）。与本主题相关的是，Bruemmer 等人报道，骨桥蛋白的缺失减少了输注血管紧张素 II 的小鼠腹主动脉瘤 (AAA) 的形成。 8
Osteopontin is an arginine-glycine–aspartate (RGD) containing adhesive glycoprotein first identified in bone but subsequently detected in many other tissues, including, dentin, cartilage, kidney, and vascular tissues. 1–3 It is expressed by a wide variety of inflammatory cells (eg, macrophages, T lymphocytes, NK cells), and, to a lesser extent, by endothelial cells and smooth muscle cells. The RGD domain facilitates tissue binding of osteopontin to various extracellular matrix proteins, such as αvß3 integrin and fibronectin. Additionally, osteopontin may engage CD44 through an RGD-independent mechanism. In extracellular fluids, osteopontin functions as a cytokine, and its plasma levels are increased in autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis. 4 The diverse biological actions of osteopontin could potentially regulate many processes pertinent to vascular disease, including inflammation, cell adhesion, viability, angiogenesis, and calcification (Figure). 5, 6 Such actions may underlie its presumed role in the pathophysiology of atherosclerosis and in modulating arteriopathy associated with diabetes and chronic renal failure (reviewed by Johnson et al7). Of relevance to the present topic, Bruemmer et al reported that deletion of osteopontin reduced formation of abdominal aortic aneurysms (AAA) in mice infused with angiotensin II. 8