Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children
Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children
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DOI：
10.1038/oby.2003.147
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发表时间：
2003-09-01
期刊：
影响因子：
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通讯作者：
Taniyama, M
中科院分区：
文献类型：
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作者：
Asayama, K;Hayashibe, H;Taniyama, M
目的：探讨肥胖儿童血清脂联素水平是否降低，治疗后是否恢复到正常水平。研究方法和方法：研究对象为53名日本肥胖儿童，33名男孩和20名女孩(6~14岁)，以及30名年龄匹配的非肥胖对照组(16名男孩和14名女孩)。在隔夜禁食后抽取血液，对肥胖儿童进行人体测量，包括腰围、臀围和皮褶厚度。配对样本来自接受心理教育治疗的21名肥胖儿童。CT测量内脏脂肪组织面积。结果：肥胖儿童血清丙氨酸氨基转移酶、尿酸、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、总胆固醇/高密度脂蛋白胆固醇、载脂蛋白B、载脂蛋白B/载脂蛋白A(1)、胰岛素水平均高于正常参考值。肥胖组儿童血清脂联素水平明显低于对照组(P<0.001)。在治疗期间超重百分比下降的21名肥胖儿童中，脂联素水平上升(p=0.002)。肥胖儿童脂联素水平与内脏脂肪组织面积呈负相关(r=-0.531，p<；0.001)。在调整超重百分比、体脂百分比或性别后，脂联素水平与丙氨酸氨基转移酶、尿酸和胰岛素呈显著负相关。讨论：肥胖儿童血清脂联素水平下降依赖于内脏脂肪的积累，并通过减肥恢复到正常水平。
Objective: To determine whether serum adiponectin is decreased in obesity and is restored toward normal level after treatment in children.Research Methods and Procedures: Subjects were 53 Japanese obese children, 33 boys and 20. girls (6 to 14 years old), and 30 age-matched nonobese controls for measuring adiponectin (16 boys and 14 girls). Blood was drawn after an overnight fast, and the obese children were subjected to anthropometric measurements including waist and hip circumferences and skinfold thicknesses. Paired samples were obtained from 21 obese children who underwent psycho-educational therapy. Visceral adipose tissue area was measured by computed tomography. Adiponectin was assayed by an enzyme-linked immunosorbent assay.Results: The serum levels of alanine aminotransferase, uric acid, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, total cholesterol/high-density lipoprotein-cholesterol, apo B, apo B/apo A(1), and insulin in obese children were higher than the reference values. Serum adiponectin level was lower in the obese children than in the controls (6.4 +/- 0.6 vs. 10.2 +/- 0.8 mg/L, means +/- SEM, p < 0.001). In 21 obese children whose percent overweight declined during therapy, the adiponectin level increased (p = 0.002). The adiponectin level was correlated inversely with visceral adipose tissue area in obese children (r = -0.531, p < 0.001). The inverse correlations of adiponectin with alanine aminotransferase, uric acid, and insulin were significant after being adjusted for percentage overweight, percentage body fat, or sex.Discussion: Serum adiponectin level is decreased in obese children depending on the accumulation of visceral fat and is restored toward normal level by slimming.