Auditory Oddball fMRI in Schizophrenia: Association of Negative Symptoms with Regional Hypoactivation to Novel Distractors
Auditory Oddball fMRI in Schizophrenia: Association of Negative Symptoms with Regional Hypoactivation to Novel Distractors
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DOI：
10.1007/s11682-008-9022-7
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Gur, Ruben C.
中科院分区：
文献类型：
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作者：
Wolf, Daniel H.;Turetsky, Bruce I.;Gur, Ruben C.
精神分裂症与显著刺激的异常处理有关，这可能导致临床症状。我们使用功能磁共振成像和一个标准的听觉三刺激任务来检查注意力处理。对17例患者和21例健康对照者进行靶刺激和新刺激物刺激，激活与阳性和阴性症状相关。针对靶点，患者的运动前皮层、前扣带皮层、颞叶皮层、脑岛、海马等多个区域过度激活，枕叶皮层失活减弱。对于干扰物，患者左腹外侧前额皮质过度激活。这种过度激活可能反映了精神分裂症患者对显著刺激的超敏反应。患者在背外侧前额叶皮层、运动前区和腹侧纹状体对新干扰物的激活与负性症状严重程度呈负相关。新奇诱导的前额皮质和腹侧纹状体活动可能是研究阴性症状的有用的中间表型。
Schizophrenia is associated with abnormal processing of salient stimuli, which may contribute to clinical symptoms. We used fMRI and a standard auditory three-stimulus task to examine attention processing. Target stimuli and novel distractors were presented to 17 patients and 21 healthy controls and activation was correlated with negative and positive symptoms. To targets, patients over-activated multiple regions including premotor cortex, anterior cingulate, temporal cortex, insula, and hippocampus, and also showed attenuated deactivation within occipital cortex. To distractors, patients overactivated left ventrolateral prefrontal cortex. This overactivation may reflect hypersensitivity to salient stimuli in schizophrenia. Patients also exhibited an inverse correlation between negative symptom severity and activation to novel distractors in the dorsolateral prefrontal cortex, premotor area, and ventral striatum. Novelty-induced activity within prefrontal cortex and ventral striatum may represent a useful intermediate phenotype for studies of negative symptoms.