The clinical manifestation of the kwashiorkor syndrome is related to increased lipid peroxidation
The clinical manifestation of the kwashiorkor syndrome is related to increased lipid peroxidation
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DOI：
10.1016/s0022-3476(98)70324-5
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发表时间：
1998-05-01
影响因子：
5.1
通讯作者：
Leichsenring, M
中科院分区：
文献类型：
--
作者：
Lenbartz, H;Ndasi, R;Leichsenring, M
沿着严重恶性营养不良症状的发作，一名20个月大的儿童表现出脂质过氧化明显增加的生化体征，血浆抗氧化剂减少，血浆和红细胞磷脂中多不饱和脂肪酸的比例降低。此外，脂质过氧化产物丙二醛和己醛的血浆浓度以及尿中白三烯E-4的排泄量也增加。随着随后的临床改善，Au生化变化沿着正常化。这些发现表明脂质过氧化程度与恶性营养不良综合征的严重程度密切相关。
Along with the onset of severe kwashiorkor symptoms, a 20-month-old child showed biochemical signs of markedly increased lipid peroxidation, with a decrease of plasma antioxidants and decreased proportions of polyunsaturated fatty acids in plasma and red cell phospholipids. Additionally, plasma concentrations of the lipid peroxidation products malondialdehyde and hexanal, as well as the urinary excretion of leukotriene E-4, were found to be increased. AU biochemical alterations normalized along with subsequent clinical improvement. These findings suggest that the extent of lipid peroxidation is strongly related to the severity of the kwashiorkor syndrome.