Human immunodeficiency virus and leishmaniasis.
Human immunodeficiency virus and leishmaniasis.
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DOI：
10.4103/0974-777x.68528
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发表时间：
2010-09
影响因子：
1.6
通讯作者：
Craft N
中科院分区：
文献类型：
--
作者：
Ezra N;Ochoa MT;Craft N
利什曼病是一组通过白蛉叮咬传播给人类的疾病，由利什曼原虫属的原生动物寄生虫引起。各种利什曼原虫感染人类，产生一系列临床表现。据估计，有3.5亿人处于危险之中，全球皮肤利什曼病（VL）的年发病率为1- 150万，内脏利什曼病（VL）的年发病率为50万。VL是东非、巴西和印度次大陆发病率和死亡率的主要原因。与人类免疫缺陷病毒（HIV）的共同感染改变了对疾病的免疫反应。在这里，我们审查的免疫反应，利什曼原虫在艾滋病毒合并感染的设置。对合并感染免疫学的进一步了解可能有助于设计针对利什曼病的预防和治疗策略。
The Leishmaniases are a group of diseases transmitted to humans by the bite of a sandfly, caused by protozoan parasites of the genus Leishmania. Various Leishmania species infect humans, producing a spectrum of clinical manifestations. It is estimated that 350 million people are at risk, with a global yearly incidence of 1-1.5 million for cutaneous and 500,000 for visceral Leishmaniasis (VL). VL is a major cause of morbidity and mortality in East Africa, Brazil and the Indian subcontinent. Co-infection with human immunodeficiency virus (HIV) alters the immune response to the disease. Here we review the immune response to Leishmania in the setting of HIV co-infection. Improved understanding of the immunology involved in co-infections may help in designing prophylactic and therapeutic strategies against Leishmaniasis.