Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy.
Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy.
复制标题
复发性细胞先天性中胚层肾瘤对化疗的完全反应。
DOI：
10.1097/00043426-200208000-00014
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Dome,JeffreyS
中科院分区：
文献类型：
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作者：
Loeb,DavidM;Hill,DAshley;Dome,JeffreyS
先天性间母细胞肾瘤（CMN）通常通过手术治愈。这种肿瘤对化疗的敏感性尚不清楚。最近对细胞性CMN和先天性婴儿纤维肉瘤中at (12; 15)（p13; q25）染色体易位的描述表明，这些实体具有共同的发病机制，并且细胞性CMN可能像先天性婴儿纤维肉瘤一样对化疗有反应。作者描述了3例复发性细胞性CMN患者，他们对化疗有完全的反应。基于这些患者和文献回顾，作者建议将化疗作为复发性或不可切除的细胞性CMN治疗的一部分。
Congenital mesoblastic nephroma (CMN) is usually cured by surgery. The sensitivity of this tumor to chemotherapy is unknown. The recent description of at (12; 15)(p13; q25) chromosomal translocation in both cellular CMN and congenital infantile fibrosarcoma suggests that these entities have a common pathogenesis, and that cellular CMN might respond to chemotherapy like congenital infantile fibrosarcoma does. The authors describe three patients with recurrent cellular CMN who showed a complete response to chemotherapy. Based on these patients and a review of the literature, the authors suggest that chemotherapy be considered as a part of the therapy for recurrent or unresectable cellular CMN.