Probing immune infiltration dynamics in cancer by in vivo imaging.
Probing immune infiltration dynamics in cancer by in vivo imaging.
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DOI：
10.1016/j.cbpa.2022.102117
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发表时间：
2022-04
影响因子：
7.8
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中科院分区：
文献类型：
--
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癌症免疫治疗通常旨在刺激细胞毒性t细胞或促炎抗原呈递细胞的积累和活性，减少免疫抑制性骨髓细胞或调节性t细胞，或引起它们的某种组合作用。尽管有令人鼓舞的结果，免疫疗法，如PD-1/ pd - l1靶向免疫检查点阻断在个体患者中的作用是不一样的。预测和监测个体反应仍然具有挑战性，特别是在多个转移部位或潜在毒性部位。为了满足这一需求，适应性和先天免疫细胞群的体内成像已经成为一种非侵入性量化肿瘤中空间白细胞积累的工具。在这里，我们回顾了体内白细胞成像探针的最新进展，重点介绍了t细胞、吞噬巨噬细胞成像及其对治疗反应的互补视角。
Cancer immunotherapies typically aim to stimulate the accumulation and activity of cytotoxic T-cells or pro-inflammatory antigen-presenting cells, reduce immunosuppressive myeloid cells or regulatory T-cells, or elicit some combination of effects thereof. Notwithstanding the encouraging results, immunotherapies such as PD-1/PD-L1-targeted immune checkpoint blockade act heterogeneously across individual patients. It remains challenging to predict and monitor individual responses, especially across multiple sites of metastasis or sites of potential toxicity. To address this need, in vivo imaging of both adaptive and innate immune cell populations has emerged as a tool to quantify spatial leukocyte accumulation in tumors non-invasively. Here we review recent progress in the translational development of probes for in vivo leukocyte imaging, focusing on complementary perspectives provided by imaging of T-cells, phagocytic macrophages, and their responses to therapy.
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