ALIEN HAND SYNDROME - INTERHEMISPHERIC MOTOR DISCONNECTION DUE TO A LESION IN THE MIDBODY OF THE CORPUS-CALLOSUM
ALIEN HAND SYNDROME - INTERHEMISPHERIC MOTOR DISCONNECTION DUE TO A LESION IN THE MIDBODY OF THE CORPUS-CALLOSUM
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DOI：
10.1212/wnl.45.4.802
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发表时间：
1995-04-01
期刊：
影响因子：
9.9
通讯作者：
ZAIDEL, E
中科院分区：
文献类型：
--
作者：
GESCHWIND, DH;IACOBONI, M;ZAIDEL, E
由于大多数病例中存在脑损伤的非限制性性质，外星人手综合症的神经解剖学基础仍然存在争议。很少有研究表明损伤仅限于胼胝体部分，大多数病例涉及因肿瘤或癫痫而进行的胼胝体切开术。我们报道了一名患有暂时性异手综合症的女性病例，该综合症是由于胼胝体中部和后部中风引起的。该病例为胼胝体中体损伤作为非优势异形手综合征的解剖学基础提供了支持性证据，并符合半球间运动断开模型作为这种异常行为综合征的基本组成部分。这种断开可能发生在涉及左半球主导运动活动的个体的胼胝体中部行进的半球间前运动纤维和运动纤维的损伤中。
The neuroanatomic substrate of the alien hand syndrome has remained controversial due to the noncircumscribed nature of cerebral injuries present in most cases. There have been few cases studied in which damage was restricted to portions of the body of the callosum, and most of those involved surgical callosotomy for tumors or epilepsy. We report the case of a woman with a transient alien hand syndrome caused by a stroke limited to the middle and posterior portions of the body of the corpus callosum. This case provides supportive evidence for damage to the midbody of the corpus callosum as the anatomic basis of nondominant alien hand syndrome and conforms to a model of interhemispheric motor disconnection as the essential component of this unusual behavioral syndrome. This disconnection can occur with injuries involving interhemispheric premotor and motor fibers traveling in the midportion of the callosum in individuals with left hemisphere dominance for motor activities.