Size and shape affects the antimicrobial activity of quaternized nanoparticles
Size and shape affects the antimicrobial activity of quaternized nanoparticles
复制标题
尺寸和形状影响季铵化纳米颗粒的抗菌活性
DOI：
10.1002/pola.29195
复制
发表时间：
2019-02-01
影响因子：
--
通讯作者：
O'Reilly, Rachel K.
中科院分区：
文献类型：
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作者：
Inam, Maria;Foster, Jeffrey C.;O'Reilly, Rachel K.
利用结晶驱动自组装技术（CDSA）制备了不同尺寸的球形或片晶状季铵化纳米粒子，探讨了尺寸和形状对其抗菌活性的影响。小的2D血小板（< 1 μ m）比大的2D血小板（约1 μ m）表现出更大的抗菌活性。4 μ m）、它们相应的球形结构和未组装的聚合物链。这种活性取决于细菌的大小、形状和细胞膜结构。
Crystallization driven self-assembly (CDSA) was utilized to prepare quaternized nanoparticles with spherical or platelet morphologies of different sizes to explore the effect of size and shape on their antibacterial activity. Small 2D platelets (< 1 mu m) exhibited greater antibacterial activity than larger 2D platelets (ca. 4 mu m), their corresponding spherical constructs, and unassembled polymer chains. This activity was dependent on the size, shape, and cell membrane structure of the bacteria.