EFFECTS ON RENAL-FUNCTION OF A LOW-NITROGEN DIET SUPPLEMENTED WITH ESSENTIAL AMINO-ACIDS AND KETOANALOGUES AND OF HEMODIALYSIS AND FREE PROTEIN SUPPLY IN PATIENTS WITH CHRONIC-RENAL-FAILURE
EFFECTS ON RENAL-FUNCTION OF A LOW-NITROGEN DIET SUPPLEMENTED WITH ESSENTIAL AMINO-ACIDS AND KETOANALOGUES AND OF HEMODIALYSIS AND FREE PROTEIN SUPPLY IN PATIENTS WITH CHRONIC-RENAL-FAILURE
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DOI：
10.1159/000182036
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发表时间：
1981-01-01
期刊：
影响因子：
2.5
通讯作者：
GIOVANNETTI, S
中科院分区：
文献类型：
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作者：
BARSOTTI, G;GUIDUCCI, A;GIOVANNETTI, S
重复测量 3 组慢性尿毒症患者的肌酐清除率。在第一个对照组（31 例）中，采用传统的低蛋白饮食后，肌酐清除率随时间线性下降。在第二组（12 例）中，采用极低氮饮食并补充必需氨基酸和酮类似物后，肌酐清除率实际上保持恒定，只有 1 例例外，肌酐清除率继续下降。在重复透析治疗的第三组尿毒症患者（13例）中，肌酐清除率的恶化明显加速。讨论了这些发现的可能解释和实际意义。
Creatinine clearance was repeatedly measured in 3 groups of chronic uremics. In the 1st control group (31 cases), following a conventional low-protein diet, creatinine clearance declined linearly with time. In the 2nd group (12 cases), following a very low nitrogen diet supplemented with essential amino acids and ketoanalogs, creatinine clearance remained practically constant with only 1 exception in which it continued to decline. In the 3rd group of uremics (13 cases) on repeated dialysis therapy, the deterioration creatinine clearance was markedly accelerated. The possible explanations and the practical implications of these findings are discussed.