The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37°C
The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37°C
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DOI：
10.1016/s0939-6411(02)00121-2
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发表时间：
2002-11-01
影响因子：
4.9
通讯作者：
Ring, SG
中科院分区：
文献类型：
--
作者：
Leong, CW;Newton, JM;Ring, SG
通过测量最低成膜温度（MFFF），研究了在一定浓度的增塑剂存在下，与一定比例的直链淀粉/丁醇络合物混合的商业乙基纤维素水分散体（Surelease）的成膜性能。与文献中预期的相反，研究发现，通常存在于乙基纤维素分散体标准配方中的额外4%的增塑剂（癸二酸二丁酯）足以降低MFFT，以允许在35度下形成薄膜。用动态力学分析方法对35℃下浇铸和干燥制备的自由膜的玻璃化转变温度进行了评价，证实了这一点。该技术还证明了乙基纤维素和直链淀粉不能混溶。利用间歇式发酵罐证实了粪浆对低温下形成的膜的消化能力。消化的程度与薄膜中直链淀粉的含量直接相关，从而保证了提供薄膜的潜力，这些薄膜可以作为结肠特异性涂层。(C) 2002 Elsevier Science B.V.版权所有
The film forming properties of a commercial aqueous ethylcellulose dispersion (Surelease) mixed with a range of ratios of an amylose/butanol complex in the presence of a range of concentrations of a plasticiser has been studied by measuring the minimum film forming temperature (MFFF). Contrary to what was to be anticipated from the literature, it was found that an additional 4% of the plasticiser (dibutyl sebacate), normally present in the standard formulation of the ethyl cellulose dispersion, was sufficient to lower the MFFT to allow the formation of films at 35degreesC. This was confirmed by assessment of the glass transition temperature of free films prepared by casting and drying at 35degreesC by the application of dynamic mechanical analysis. This technique also demonstrated that the ethylycellulose and the amylose were not miscible. The ability of faecal slurry to digest the films formed at low temperatures was confirmed by the use of a batch fermenter. The extent of digestion was directly related to the amylose content of the films, ensuring the potential to provide films, which could function as colon specific coatings. (C) 2002 Elsevier Science B.V. All rights reserved.