Dietary Calcium and Magnesium Intake and Mortality: A Prospective Study of Men
Dietary Calcium and Magnesium Intake and Mortality: A Prospective Study of Men
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DOI：
10.1093/aje/kwp467
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发表时间：
2010-04-01
影响因子：
5
通讯作者：
Wolk, Alicja
中科院分区：
文献类型：
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作者：
Kaluza, Joanna;Orsini, Nicola;Wolk, Alicja
作者研究了23，366名年龄在45-79岁之间的瑞典男性的膳食钙和镁摄入量与全因心血管疾病（CVD）和癌症死亡率的关系，这些男性没有使用膳食补充剂。采用考克斯比例风险回归模型估计死亡率的多变量风险比和95%置信区间。从1998年基线至2007年12月，瑞典人口登记处记录了2，358例各种原因的死亡;到2006年12月，瑞典死因登记处记录了819例心血管疾病死亡和738例癌症死亡。膳食钙与统计学显著降低的全因死亡率相关（风险比（HR）= 0.75，95%置信区间（CI）：0.63，0.88; P趋势< 0.001）和CVD发生率无显著性降低（HR = 0.77，95% CI：0.58，1.01; P趋势= 0.064），但不是癌症死亡率（HR = 0.87，95% CI：0.65，1.17; P趋势= 0.362）（平均值= 1，953 mg/天;标准差（SD），334）与最低值（990 mg/天; SD，187）进行比较。膳食镁摄入量（三分位数均值范围为387 mg/天（SD，31）至523 mg/天（SD，38））与全因、CVD或癌症死亡率无关。这项以人群为基础的前瞻性研究对膳食钙和镁摄入量相对较高的男性进行了研究，结果表明，每日钙摄入量高于推荐摄入量可能会降低全因死亡率。
The authors examined the association of dietary calcium and magnesium intake with all-cause, cardiovascular disease (CVD), and cancer mortality among 23,366 Swedish men, aged 45-79 years, who did not use dietary supplements. Cox proportional hazards regression models were used to estimate the multivariate hazard ratios and 95% confidence intervals of mortality. From baseline 1998 through December 2007, 2,358 deaths from all causes were recorded in the Swedish population registry; through December 2006, 819 CVD and 738 cancer deaths were recorded in the Swedish cause-of-death registry. Dietary calcium was associated with a statistically significant lower rate of all-cause mortality (hazard ratio (HR) = 0.75, 95% confidence interval (CI): 0.63, 0.88; P-trend < 0.001) and a nonsignificantly lower rate of CVD (HR = 0.77, 95% CI: 0.58, 1.01; P-trend = 0.064) but not cancer mortality (HR = 0.87, 95% CI: 0.65, 1.17; P-trend = 0.362) when the highest intake tertile (mean = 1,953 mg/day; standard deviation (SD), 334) was compared with the lowest (990 mg/day; SD, 187). Dietary magnesium intake (means of tertiles ranged from 387 mg/day (SD, 31) to 523 mg/day (SD, 38) was not associated with all-cause, CVD, or cancer mortality. This population-based, prospective study of men with relatively high intakes of dietary calcium and magnesium showed that intake of calcium above that recommended daily may reduce all-cause mortality.