Concentrations of Glucagon and the Insulin: Glucagon Ratio in the Portal and Peripheral Circulation 1
Concentrations of Glucagon and the Insulin: Glucagon Ratio in the Portal and Peripheral Circulation 1
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胰高血糖素和胰岛素的浓度：门静脉和外周循环中的胰高血糖素比率 1
DOI：
10.3181/00379727-147-38286
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发表时间：
1974
影响因子：
--
通讯作者：
J. Kinney
中科院分区：
文献类型：
--
作者：
P. Felig;R. Gusberg;R. Hendler;F. Gump;J. Kinney
摘要 在通过脐静脉导管研究的吸收后状态的术后患者中，门静脉血中胰高血糖素和胰岛素的浓度超过了外周静脉血中的浓度。然而，胰岛素的门脉-外周梯度（1.8-4.0）始终大于胰高血糖素的门脉-外周梯度（1.1-1.5）。因此，门静脉中的胰岛素：胰高血糖素 (I/G) 摩尔比比外周血中高 100%。然而，在门静脉和外周 I/G 摩尔比之间观察到直接线性相关。数据表明，外周测量低估了门静脉血中胰岛素与胰高血糖素的绝对比率，但仍然提供了肝循环中相对激素可用性的指数。
Summary In postoperative patients studied in the postabsorptive state by mean of an umbilical vein catheter, concentrations of glucagon and insulin in portal blood exceeded those in peripheral venous blood. However, the portal—peripheral gradient for insulin (1.8-4.0) was consistently greater than that observed for glucagon (1.1-1.5). Consequently, the insulin:glucagon (I/G) molar ratio in the portal vein was 100% higher than in peripheral blood. A direct linear correlation however, was observed between portal and peripheral I/G molar ratios. The data indicate that peripheral measurements underestimate the absolute ratio of insulin to glucagon in portal blood, but nevertheless provide an index of relative hormonal availability in the hepatic circulation.