In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites
In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites
复制标题
红紫素 18 肽缀合物原位形成纳米纤维以及组装诱导的肿瘤位点保留效应
DOI：
10.1002/adma.201502598
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发表时间：
2015-10-28
影响因子：
29.4
通讯作者：
Wang, Hao
中科院分区：
文献类型：
--
作者：
Zhang, Di;Qi, Guo-Bin;Wang, Hao
描述了用于增强肿瘤光声（PA）成像和治疗的组装诱导保留效应。制备了一种响应性小分子前体，其同时在肿瘤部位自组装成纳米纤维，其表现出组装诱导的保留效应，这导致改善的PA成像信号和增强的治疗功效。这项成功的概念验证研究为开发用于癌症诊断和治疗的新型超分子生物材料铺平了道路。
An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.